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pentobarbital will lower the level or effect of tamoxifen by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.pentobarbital will decrease the extent or outcome of norgestrel by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Closely. Moderate CYP3A4 inducers may well decrease progestin concent